History of Chemical and Biological Warfare Agents

Hi spirit level of Chemical and biologic fightf be Agents biologic state of war (BW), withal known as germ warf be, is the exercise of pathogens such as viruses, bacteria, other unsoundness-causing biological actors, or the toxins produced by them as biological weapons (or bioweapons). in that respect is a clear overlap between biological warfargon and chemical warfare, as the use of toxins produced by living existences is considered under the provisions of two the Biological and Toxin artillerys Convention and the Chemical Weapons Convention. Toxins, which are of organic origin, are practic each(prenominal)y called midspectrum agents.A biological weapon whitethorn be intended to kill, incapacitate, or seriously impair a person, group of people, or even an total mankind. It may likewise be defined as the real(a) or defense against such employment.Biological warfare is a military proficiency that outhouse be utilise by nation-states or non-national groups. In the la tter(prenominal) event, or if a nation-state uses it clandestinely, it may to a fault be considered bioterrorism.HistoryBiological warfare has been practiced repeatedly through turn out history. Before the 20th century, the use of biological agents took three major formsDeliberate poisoning of food and water with infectious materialUse of micro-organisms, toxins or animals, living or dead, in a weapon transcriptionUse of biologically inoculated fabricsThe ancient areaThe earliest documented incident of the intention to use biological weapons is pre dole out in Hittite texts of 1500-1200 B.C, in which victims of aversion were driven into enemy lands. Although the Assyrians knew of ergot, a parasitic fungus of rye which produces ergotism when ingested, at that place is no evidence that they pois sensationd enemy s thoroughly with the fungus, as has been claimed.According to Homers epic poems more or less the legendary Trojan war, the Iliad and the Odyssey, spears and curso rs were tip with poison. During the freshman Sacred War in Greece, in virtually 590 BC, capital of Greece and the Amphictionic League poisoned the water supply of the beleaguer town of Kirrha (near Delphi) with the toxic give hellebore. The Roman commander Manius Aquillus poisoned the wellheads of besieged enemy cities in about 130 BC.During the 4th century BC Scythian archers tipped their arrow tips with snake venom, human blood, and animal feces to practice wounds to become infected. in that respect are numerous other instances of the use of be toxins, venoms, and other savage substances to create biological weapons in antiquity.In 184 B.C, Hannibal of Carthage had clay pots filled with sulphurous snakes and instructed his soldiers to throw the pots onto the decks of Pergamene ships. In about AD 198, the urban center of Hatra (near Mosul, Iraq) repulsed the Roman forces led by Septimius Severus by hurling clay pots filled with support scorpions at them.Medieval biolo gical warfareWhen the Mongol Empire accomplished commercial and political connections between the einsteiniumern and Western areas of the world, its Mongol armies and merchant caravans probably inadvertently brought bubonic plague from central Asia to the Middle East and Europe. The Black wipeout swept through Eurasia, killing approximately one third to one half of the population and changing the crinkle of Asiatic and European history.During the Middle Ages, victims of the bubonic plague were used for biological attacks, much by flinging corpses and excrement over castle walls using catapults. In 1346, the bodies of Mongol warriors of the Golden Horde who had died of plague were thrown over the walls of the besieged Crimean city of Kaffa (now Theodosia). It has been speculated that this operation may defend been responsible for the advent of the Black Death in Europe.At the siege of Thun lEveque in 1340, during the Hundred Years War, the attackers catapulted decomposing an imals into the besieged area.Modern timesThe 18th CenturyThe Native Ameri screwing population was decimated after contact with the Old humans collectible to the introduction of legion(predicate) different fatal diseases. thither are two documented parapraxiss of supposed and attempted germ warfare. The first, during a parley at Fort Pitt on June 24, 1763, Ecuyer gave representatives of the besieging Delawares two blankets and a handkerchief that had been exposed to smallpox, hoping to spread the disease to the Natives in order to end the siege. William Trent, the militia commander, left records that clearly indicated that the project of giving the blankets was to Convey the infinitesimalpox to the Indians.British commander Lord Jeffrey Amherst and Swiss-British incumbent Colonel Henry Bouquet, whose cor actence referenced the idea of giving smallpox-infected blankets to Indians in the course of Pontiacs Rebellion. Historian Francis Parkman verifies four letters from June 29, July 13, 16 and 26th, 1763. Excerpts Commander Lord Jeffrey Amherst writes July 16, 1763, P.S. You allow for Do well to try to Inocculate the Indians by means of Blankets, as well as to try Every other method that can serve to Extirpate this Execrable Race. I should be very glad your abstract for Hunting them Down by Dogs could take Effect, Colonel Henry Bouquet replies July 26, 1763, I received yesterday your Excellencys letters of 16th with their Inclosures. The signal for Indian Messengers, and all your directions will be observed. eyepatch the intent for biological warfare is clear, there is a debate among historians as to whether this actually took place despite Bouquets favorable reply to Amherst and each having written to the other about it twice. Smallpox convey to Native American tribes could have been due to the transfer of the disease to blankets during transportation. Historians have been unable to establish whether or non this plan was implemented, pointly in lig ht of the fact that smallpox was already present in the region, and that scientific knowledge of disease at that time had just to discover bacteria or develop an understanding of plague vectors.Regardless of whether this plan was carried out, profession and combat postd ample opportunity for transmission of the disease. See also Small pox during Pontiacs Rebellion.The 19th CenturyIn 1834 Cambridge Diarist Richard Henry Dana visited San Francisco on a merchant ship. His ship traded many items including blankets with Mexicans and Russians who had established outposts on the Union side of the San Francisco Bay.Local histories document that the California smallpox epidemic began at the Russian fort soon after they left. Blankets were a popular profession item, and the cheapest source of them was second-hand blankets which were often contaminated.During the American Civil War, General Sherman reported that allied forces shot farm animals in ponds upon which the Union depended for d rinking water. This would have make the water unpleasant to drink, although the actual health risks from dead bodies of humans and animals which did non die of disease are minimal.Jack London in his story Yah Yah Yah describes a punitive European expedition to a Pacific island designedly exposing the Polynesian population to Measles, of which many of them died sSouth Sea Tales/Yah Yah Yah. While much of the material for Londons South Sea Tales is derived from his personal experience in the region, it is not certain that this particular incident is historical.The 20th CenturyDuring the First World War, Germany pursued an ambitious biological warfare program. Using diplomatic pouches and couriers, the German General Staff supplied small teams of saboteurs in the Russian dukedom of F landlocked, and in the accordingly-neutral countries of Romania, the US and Argentina.In Finland, Scandinavian freedom fighters mounted on reindeer placed ampules of anthrax in stables of Russian ho rses in 1916. anthrax was also supplied to the German military attache in Bucharest, as was Glanders, which was diligent against livestock destined for Allied service.German intelligence officer and US citizen Dr. Anton Casimir Dilger established a secret lab in the basement of his sisters shoes in Chevy Chase, Maryland, that produced Glanders which was used to infect livestock in ports and inland collection points including, at least, Newport News, Norfolk, Baltimore, and New York, and probably St. Louis and Covington, Kentucky. In Argentina, German agents also employed Glanders in the port of Buenos Aires and also tried to ruin stalk harvests with a destructive fungus.During the 1948 Israel War of Independence, Red Cross reports raised suspiciousness that the Jewish Haganah militia had released Salmonella typhi bacteria into the water supply for the city of Acre, causing an eruption of typhoid among the inhabitants. Egyptian troops later captured disguised Haganah soldiers ne ar wells in Gaza, whom they executed for allegedly attempting another attack. Israel denies these allegations.During the Cold War, US conscientious objectors were used as consenting test subjects for biological agents in a program known as Operation Whitecoat. There were also many unpublicized tests carried out on the public during the Cold War.E120 biological bomblet, essential before the U.S. signed the Biological and Toxic Weapons ConventionConsiderable inquiry on the topic was performed by the joined States (see US Biological Weapon Testing), the Soviet Union, and probably other major nations throughout the Cold War era, though it is world-widely believed that biological weapons were never used after World War II. This view was challenged by China and North Korea, who accused the United States of large-scale field testing of biological weapons, including the use of disease-carrying insects against them during the Korean War (1950-1953).Biological agentsBiological warfare is t he deliberate use of disease and inherent poisons to incapacitate humans. It employs pathogens as weapons. Pathogens are the micro-organism, whether bacterial, viral or protozoic, that cause disease. There are four kinds of biological warfare agents bacteria, viruses, rickettsiae and fungi. Biological weapons are magisterial by being living organisms, that reproduce within their host victims, who then become contagious with a deadly, if weakening, multiplier pith. Toxins in contrast do not reproduce in the victim and need solitary(prenominal) the briefest of brooding periods they kill within a few hours.Biological Weapons CharacteristicsAnti-personnel BW perfect characteristics of biological weapons rumping humans are high infectivity, high potency, non-availability of vaccines, and delivery as an aerosol.Diseases most likely to be considered for use as biological weapons are contenders because of their lethality (if delivered efficiently), and robustness (making aerosol delive ry feasible).The biological agents used in biological weapons can often be manufactured quickly and easily. The primary fuss is not the production of the biological agent notwithstanding delivery in an effective form to a vulnerable target.For example, anthrax is considered an effective agent for several reasons. First, it forms hardy spores, perfect for dispersal aerosols. Second, pneumonic (lung) contagions of anthrax ordinarily do not cause secondary transmissions in other people. Thus, the effect of the agent is usually confined to the target. A pneumonic anthrax infection starts with ordinary cold symptoms and quickly becomes lethal, with a fatality rate that is 90% or higher. Finally, friendly personnel can be protected with satisfactory antibiotics.A mass attack using anthrax would expect the creation of aerosol particles of 1.5 to 5 micrometres. Too large and the aerosol would be filtered out by the respiratory system. Too small and the aerosol would be inhaled and exha led. Also, at this size, nonconductive powders tend to clump and cling because of electrostatic charges. This hinders dispersion. So the material must be treated to insulate and discharge the charges. The aerosol must be delivered so that rain and sun does not rot it, and yet the human lung can be infected. There are other expert difficulties as well.Diseases considered for weaponization, or known to be weaponized overwhelm anthrax , ebola, Marburg virus, plague , cholera , tularemia, brucellosis, Q fever, Bolivian hemorrhagic fever, Coccidioides mycosis , Glanders, Melioidosis, Shigella, Rocky Mountain spotty fever, typhus , Psittacosis, yellow fever , Japanese B encephalitis , break Valley fever, and smallpox 1931. Naturally-occurring toxins that can be used as weapons include ricin, SEB, botulism toxin, saxitoxin, and many mycotoxins. The organisms causing these diseases are known as select agents. In the United States, their possession, use, and transfer are regulated by th e Centers for Disease instruction and Preventions Select Agent Program.Anti-agriculture BWBiological warfare can also detailally target plant lifes to destroy crops or defoliate vegetation. The United States and Britain notice plant growth regulators (i.e., herbicides) during the Second World War, and initiated an herbicidal warfare program that was in conclusion used in Malaya and Vietnam in counter insurgency. Though herbicides are chemicals, they are often grouped with biological warfare as bioregulators in a similar manner as biotoxins. Scorched earth tactics or destroying livestock and farmland were carried out in the Vietnam war and Eelam War in Sri Lanka.The United States developed an anti-crop capability during the Cold War that used plant diseases (bioherbicides, or mycoherbicides) for destroying enemy agriculture. It was believed that destruction of enemy agriculture on a strategic scale could thwart Sino-Soviet aggression in a componentral war. Diseases such as whea t blast and rice blast were weaponized in aerial spray tanks and cluster bombs for delivery to enemy water sheds in agricultural regions to initiate epiphytotics (epidemics among plants). When the United States renounced its offensive biological warfare program in 1969 and 1970, the vast majority of its biological arsenal was composed of these plant diseases.In 1980s Soviet Ministry of Agriculture had successfully developed variants of foot-and-mouth disease and rinderpest against cows, African swine fever for pigs, and psittacosis to kill chicken. These agents were prepared to spray them down from tanks prone to airplanes over hundreds of miles. The secret program was code-named Ecology biodefenceRole of public health departments and disease surveillanceIt is important to demean that all of the classical and modern biological weapons organisms are animal diseases, the only exception being smallpox. Thus, in any use of biological weapons, it is exceedingly likely that animals wi ll become ill either simultaneously with, or perhaps earlier than humans.Indeed, in the largest biological weapons accident known- the anthrax outbreak in Sverdlovsk (now Yekaterinburg) in the Soviet Union in 1979, sheep became ill with anthrax as far as 200 kilometers from the release point of the organism from a military facility in the southeastern portion of the city (known as Compound 19 and still off limits to visitors today, see Sverdlovsk anthrax leak).Thus, a robust surveillance system involving human clinicians and veterinarians may find out a bioweapons attack early in the course of an epidemic, permitting the prophylaxis of disease in the vast majority of people (and/or animals) exposed but not yet ill.For example in the case of anthrax, it is likely that by 24 36 hours after an attack, some small percentage of individuals (those with compromised immune system or who had received a large dose of the organism due to proximity to the release point) will become ill with classical symptoms and signs (including a virtually unique chest X-ray finding, often recognized by public health officials if they receive timely reports). By making these entropy available to local public health officials in real time, most models of anthrax epidemics indicate that more than 80% of an exposed population can receive antibiotic treatment before becoming symptomatic, and thus repress the moderately high mortality of the disease.Identification of bioweaponsThe goal of biodefense is to shuffle the sustained efforts of the national and homeland security, checkup, public health, intelligence, diplomatic, and law enforcement communities. Health sell providers and public health officers are among the first lines of defense. In some countries private, local, and provincial (state) capabilities are being augmented by and coordinated with federal assets, to provide layered defenses against biological weapons attacks. During the first Gulf War the United Nations activat e a biological and chemical response team, Task Force Scorpio, to respond to any potential use of weapons of mass destruction on civilians.The conventional approach toward protecting agriculture, food, and water focusing on the natural or unintentional introduction of a disease is being strengthened by focused efforts to address current and anticipated future biological weapons threats that may be deliberate, multiple, and repetitive.The growing threat of biowarfare agents and bioterrorism has led to the development of specific field tools that perform on-the-spot analysis and identification of encountered suspect materials. maven such technology, being developed by researchers from the Lawrence Livermore National Laboratory (LLNL), employs a sandwich immunoassay, in which fluorescent dye-labeled antibodies aimed at specific pathogens are attached to silver and gold nanowires.Biological agentA sampling of boron anthracis-AnthraxA biological agent is a bacterium, virus, prion, fun gus, or biological toxin that can be used in bioterrorism or biological warfare. much than 1200 different kinds of biological agents have been described and studied to date. Applying a intercommunicateably broader definition, some eukaryotes (for example parasites) and their associated toxins can be considered as biological agents.Biological agents have the ability to adversely affect human health in a variety of ways, ranging from relatively mild allergic reactions to serious medical conditions, even death. These organisms are ubiquitous in the natural environment they are found in water, soil, plants, and animals. Because many biological agents reproduce rapidly and require minimal resources for preservation, they are a potential danger in a wide variety of occupational settings.Antibiotic oppositeAntibiotic guard is a specific type of drug opposite when a microorganism has the ability of withstanding the effects of antibiotics. Antibiotic resistance evolves via natural sele ction playacting upon random fun, but it can also be engineered by applying an evolutionary stress on a population. Once such a gene is generated, bacteria can then transfer the genetic information in a plain fashion (between individuals) by conjugation, transduction, or transformation. Many antibiotic resistance genes reside on plasmids, facilitating their transfer. If a bacterium carries several resistance genes, it is called multi disgustful or, informally, a superbug. The term antimicrobial resistance is sometimes used to explicitly encompass organisms other than bacteria.Antibiotic resistance can also be introduced artificially into a microorganism through laboratory protocols, sometimes used as a selectable marker to examine the mechanisms of gene transfer or to identify individuals that absorbed a piece of DNA that included the resistance gene and another gene of interest.CausesThe widespread use of antibiotics both deep down and outside of medicine is playing a significa nt role in the emergence of disgustful bacteria. They are often used in animals but also in other industries which at least in the case of agricultural use lead to the spread of resistant strains to human populations. In some countries antibiotics are sold over the counter without a prescription drug which compounds the problem. In human medicine the major problem of the emergence of resistant bacteria is due to misuse and overuse of antibiotics by doctors as well as patients. Other practices alter towards resistance include the addition of antibiotics to the fall of livestock. Household use of antibacterials in soaps and other products, although not clearly contributing to resistance, is also discouraged (as not being effective at infection control). Also unsound practices in the pharmaceutical manufacturing industry can direct towards the likelihood of creating antibiotic resistant strains.Certain antibiotic classes are super associated with colonisation with superbugs compar ed to other antibiotic classes. The risk for colonisation increases if there is a lack of sensitivity (resistance) of the superbugs to the antibiotic used and high tissue keenness as well as broad spectrum activity against good bacteria. In the case of MRSA, increased rates of MRSA infections are seen with glycopeptides, cephalosporins and especially quinolones. In the case of colonisation with C difficile the high risk antibiotics include cephalosporins and in particular quinolones and clindamycin.MechanismsAntibiotic resistance can be a result of horizontal gene transfer,30 and also of unlinked point mutations in the pathogen genome and a rate of about 1 in 108 per chromosomal replication. The antibiotic action against the pathogen can be seen as an environmental pressure those bacteria which have a mutation allowing them to survive will live on to reproduce. They will then pass this trait to their offspring, which will result in a fully resistant colony.The four main mechanisms by which microorganisms exhibit resistance to antimicrobials are medicine inactivation or modification e.g. enzymatic deactivation of Penicillin G in some penicillin-resistant bacteria through the production of -lactamases.Alteration of target site e.g. alteration of PBP-the binding target site of penicillins-in MRSA and other penicillin-resistant bacteria.Alteration of metabolic pathway e.g. some sulfonamide-resistant bacteria do not require para-aminobenzoic acid (PABA), an important precursor for the synthesis of folic acid and nucleic acids in bacteria inhibited by sulfonamides. Instead, like mammalian cells, they turn to utilizing preformed folic acid. cut back drug accumulation by decreasing drug permeability and/or increasing active efflux (pumping out) of the drugs across the cell surface.Conclusion unique(predicate) consensus recommendations are made regarding the diagnosis of anthrax, indications for vaccination, therapy for those exposed, postexposure prophylaxis, deconta mination of the environment, and additional research needs.Of the numerous biological agents that may be used as weapons, the Working Group on Civilian Biodefense has identified a limited number of organisms that could cause disease and deaths in sufficient numbers to cripple a city or region. Anthrax is one of the most serious of these diseases.